Yards/Game | Adrian Peterson | MIN | 4.11.2007 | 296 |
| Jamal Lewis | BAL | 14.12.2003 | 295 |
| Jerome Harrison | CLE | 20.12.2009 | 286 |
Yards/Season | Eric Dickerson | LAR | 1984 | 2,105 |
| Adrian Peterson | MIN | 2012 | 2,097 |
| Jamal Lewis | BAL | 2003 | 2,066 |
Yards/Career | Emmitt Smith | DAL/ARI | 1990-2004 | 18,355 |
| Walter Payton | CHI | 1975-1987 | 16,726 |
| Frank Gore | SF/IND/MIA/BUF/NYJ | 2005-2020 | 16,000 |
| | | | . |
TD/Game | Ernie Nevers | CHC | 28.9.1929 | 6 |
| Alvin Kamara | NO | 25.12.2020 | 6 |
| Jimmy Conzelman | RI | 15.10.1922 | 5 |
| Jim Brown | CLE | 1.11.1959 | 5 |
| Cookie Gilchrist | BUF | 8.12.1963 | 5 |
| James Stewart | JAX | 12.10.1997 | 5 |
| Clinton Portis | DEN | 7.12.2003 | 5 |
TD/Season | LaDainian Tomlinson | SD | 2006 | 28 |
| Priest Holmes | KC | 2003 | 27 |
| Shaun Alexander | SEA | 2005 | 27 |
TD/Career | Emmitt Smith | DAL/ARI | 1990-2004 | 164 |
| LaDainian Tomlinson | SD/NYJ | 2001-2011 | 145 |
| Marcus Allen | LAI/KC | 1982-1997 | 123 |
| | | | . |
Run/Longest | Tony Dorsett | DAL | 3.1.1983 | 99 |
| Derrick Henry | TEN | 6.12.2018 | 99 |
| Ahman Green | GB | 28.12.2003 | 98 |
| Ronald Jones | TB | 15.11.2020 | 98 |
*neu
Historische Teamkürzel:
CHC: Chicago Cardinals, LAI: Los Angeles Raiders, RI: Rock Island Independents, SD: San Diego Chargers
Stand bis und mit Season 2022