INT/Game | Sammy Baugh | WAS | 4.11.1943 | 4 |
| Dan Sandifer | WAS | 31.10.1948 | 4 |
| Don Doll | DET | 23.10.1949 | 4 |
| Bob Nussbaumer | CHC | 13.11.1949 | 4 |
| Russ Craft | PHI | 24.9.1950 | 4 |
| Bobby Dillon | GB | 26.11.1953 | 4 |
| Jack Butler | PIT | 13.12.1953 | 4 |
| Austin Gonsoulin | DEN | 18.9.1960 | 4 |
| Jerry Norton | SLC | 20.11.1960 | 4 |
| Dave Baker | SF | 4.12.1960 | 4 |
| Jerry Norton | SLC | 26.11.1961 | 4 |
| Bobby Ply | DTX | 16.12.1962 | 4 |
| Bobby Hunt | KC | 4.10.1964 | 4 |
| Willie Brown | DEN | 15.11.1964 | 4 |
| Dick Anderson | MIA | 3.12.1973 | 4 |
| Willie Buchanon | GB | 24.9.1978 | 4 |
| Deron Cherry | KC | 29.9.1985 | 4 |
| Kwamie Lassiter | ARI | 27.12.1998 | 4 |
| Deltha O'Neal | DEN | 7.10.2001 | 4 |
| DeAngelo Hall | WAS | 24.10.2010 | 4 |
INT/Season | Dick Lane | LAR | 1952 | 14 |
| Dan Sandifer | WAS | 1948 | 13 |
| Orban Sanders | NYY | 1950 | 13 |
| Lester Hayes | OAK | 1980 | 13 |
INT/Career | Paul Krause | WAS/MIN | 1964-1979 | 81 |
| Emlen Tunnell | NYG/GB | 1948-1961 | 79 |
| Rod Woodson | PIT/SF/BAL/OAK | 1987-2003 | 71 |
INT/TD | Rod Woodson | PIT/SF/BAL/OAK | 1987-2003 | 12 |
| Darren Sharper | GB/MIN/NO | 1997-2010 | 11 |
| Charles Woodson | OAK/GB | 1998-2015 | 11 |
| | | | . |
Sacks/Game | Derrick Thomas | KC | 11.11.1990 | 7.0 |
| Fred Dean | SF | 13.11.1983 | 6.0 |
| Derrick Thomas | KC | 6.9.1998 | 6.0 |
| Osi Umenyiora | NYG | 30.9.2007 | 6.0 |
| Adrian Clayborn | ATL | 19.11.2017 | 6.0 |
Sacks/Season | Michael Strahan | NYG | 2001 | 22.5 |
| T.J. Watt | PIT | 2021 | 22.5 |
| Mark Gastineau | NYJ | 1984 | 22.0 |
| Jared Allen | MIN | 2011 | 22.0 |
| Justin Houston | KC | 2014 | 22.0 |
Sacks/Career | Bruce Smith | BUF/WAS | 1985-2003 | 200.0 |
| Reggie White | PHI/GB/CAR | 1985-1998/2000 | 198.0 |
| Kevin Greene | LAR/PIT/CAR/SF | 1985-1999 | 160.0 |
*neu
Anmerkung: Sacks werden erst seit 1982 offiziell erhoben.
Historische Teamkürzel:
CHC: Chicago Cardinals, DTX: Dallas Texans, NYY: New York Yanks, OAK: Oakland Raiders, SLC: St. Louis Cardinals
Stand bis und mit Season 2022